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The FDA-approved labeling for semaglutide and tirzepatide doesn't specify a maximum treatment duration, suggesting long-term use is an acceptable clinical approach for appropriate patients

Additional exclusion considerations in clinical research design: Severe renal impairment (eGFR below 30 mL/min/1.73m2)

From a psychological perspective, engaging in exercise fosters feelings of accomplishment, diminishes stress levels, and encourages social engagement, all of which collectively enhance mood and overall mental well-being [13]