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In addition, intracellular hydrogen peroxide may differentially activate various components of the inhibitor of B (IB) kinase (IKK)-complex, as overexpression of GPx-1 in MCF-7 breast cancer cells inhibits ROS-mediated upregulation of IKK and not IKK kinases (224)

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doi: 10.1016/j.canlet.2017.12.035 154 JianSLChenWWSuYCSuYWChuangTHHsuSCet al