Common side effects include nausea, vomiting, diarrhea and constipation, and the low number of users ages 12 to 17 has made it difficult to study their impact on minors
Joo MS, Kim WD, Lee KY, Kim JH, Koo JH, Kim SG (2016) AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550
Parichatikanond, W., Nishimura, A., Nishida, M
The immune-stromal landscape of HS: orchestrating the transition from innate activation to tertiary lymphoid structures and irreversible tissue alterations The molecular mechanisms as well as cellular and immune contribution underlying HS pathogenesis, still remain incompletely defined, because of a severe lack of reliable preclinical models [64]
Gradual cold exposure may help the body adapt, but sudden exposure to very cold environments can be uncomfortable