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Ongoing phase 3 trials are in progress, and CagriSema is currently under FDA review, with a decision expected in late 2026

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In the ESSENCE trial involving participants with biopsy-confirmed MASH and stage 2 or 3 fibrosis, over half of whom had T2DM, interim analysis at 72 weeks showed 63% of those treated with semaglutide 2.4 mg weekly achieved resolution of steatohepatitis without worsening of fibrosis, compared with 34% in the placebo group

In mouse models of muscle atrophy, apitegromab increased overall lean mass, muscle size and muscle force 11,15