In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]
Often appears as a pink, red, or skin-colored lesion May present as a nodule, patch, or ulcer Can be mistaken for benign skin conditions such as eczema or psoriasis Lacks the dark coloration commonly associated with melanoma Biological behavior Because it is harder to identify visually, diagnosis is often delayed Delayed detection can allow for progression to more advanced stages Like other melanomas, it can become invasive and spread if not treated early Importance Amelanotic melanoma can be easily overlooked due to its atypical appearance
Endocrine (2020) 70:2928
(2017) 18:E1649
This change in body composition intensifies the risk of diabetes, cardiovascular disease, dyslipidemia (abnormal levels of lipids in the blood) and metabolic dysfunction-associated steatotic (fatty) liver disease