tirzepatide hfpef trial Lilly's Reduces Heart Failure Worsening for With Obesity STEP-HFpEF Trial

Significantly less

Marie Antoinette syndrome

In exchange, Novo Nordisk received a three-year exemption from the pharmaceutical tariffs the administration announced, tariffs that would otherwise apply at 100% to patented drugs imported without a Most Favored Nation (MFN) pricing agreement

NICE technology appraisal TA875 recommends it for adults with a BMI 35 kg/m (or 30 kg/m in certain higher-risk groups) and at least one weight-related comorbidity, used within a specialist weight management service for a maximum of two years

At Week 68, the BMI was missing for 2.2% and 7.5% of patients randomized to WEGOVY injection and placebo, respectively