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Heterologous expression of an engineered bifunctional bacterial GSH biosynthetic enzyme (GshF) in mitochondria enables mitochondrial GSH production and ameliorates the metabolic and proliferative defects caused by its depletion

SAC, SPG, PGW, JVF, AJS, and TN performed RNA-Seq analysis

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Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, et al

Hence the administration of natural antioxidant, alpha-tocopherol was introduced with L-Norvaline to counteract this effect