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In recent years, emerging allosteric modulators have been developed that recognize allosteric sites other than orthosteric sites and modulate receptor activation by changing the conformation of the receptor 7,8 , which has the advantages of high selectivity, overcoming resistance to orthosteric modulators, and expanding the concept of target sites

Neither approach has proven superior in comparative research

This study aimed to investigate the therapeutic potential of targeting extracellular vesicle (EV) protein in reversing PTX resistance in GC cells and to delineate the underlying molecular pathways involved

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