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The problem with GLP-1 as a drug candidate had always been its half-life: less than two minutes in the bloodstream before the enzyme DPP-4 degrades it

It promotes the conversion of eumelanin (darker pigment) to pheomelanin (lighter pigment), further contributing to a lighter skin tone

The most durable recovery draws on both

This strongly suggests a sex imbalance (more men assigned to the Mildronate arm (but not explicitly stated in the publication) that precludes valid between-group comparisons (Figure 4)

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