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Such comprehensive care will make clinicians more effective stewards of these medications and positive contributors to their patients health

21 Because CCS responds poorly to chemotherapy and is histologically and clinically similar to malignant melanoma, the use of immune checkpoint inhibitors (ICIs) to treat CCS is of ongoing interest

Techniques such as liquid chromatographymass spectrometry (LC-MS), direct infusion mass spectrometry, proximity extension assays (Olink), and aptamer-based assays (SomaScan) enable detection of multidimensional biomarker patterns linked to atherosclerosis progression ( Key findings include identification of lipid species such as ceramides, sphingolipids, and glycerolipids that strongly correlate with atherosclerosis progression and cardiovascular events ( Importantly, these platforms provide a scalable approach to evaluate vascular molecular responses to therapies

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10.1016/j.neuro.2021.11.002 76 MashD