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A zinc-binding motif engineered into the intein enhances pH sensitivity and suppresses premature cleavage

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They found that this effect was mediated through a complex inter-organ crosstalk involving the gut-brain-liver axis

Decreased cholesterol levels observed in Smith-Lemli-Optiz Syndrome (SLOS) due to 7-dehydrocholesterol reductase (DHCR7) dysfunction are associated with abnormal developmental myelination 120,121