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Thus, estrogens have effects at the genomic level through ER and ER but estrogens can also exert non-genomic effect through these same receptors such as mobilization of intracellular calcium 15 , activation of PI3K 16 and adenylate cyclase 17

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Interventions: Cagrilintide, semaglutide, placebo Primary Outcome Measures: Relative change in body weight

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