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10.1186/1477-7827-11-66 189 ShenM.JiangY.GuanZ.CaoY.LiL.LiuH.et al (2017)

Furthermore, they are costly and require prolonged use, imposing significant financial burdens on women with DOR who have fertility needs

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This pattern aligns with decades of diabetes research demonstrating that while rapid glycemic improvement carries short-term risks for retinopathy progression, sustained long-term glucose control reduces the incidence and severity of diabetic eye disease