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A deficiency in thyroid hormones leads to a wide range of clinical manifestations, including fatigue, bradycardia, cold intolerance, weight gain, constipation, depression, and cognitive impairment (Taylor et al., 2024)

The standard NHS pattern is a loading phase (injections on alternate days for up to two weeks), followed by maintenance

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Any over-activity or inhibition of these systems may lead to lesions in different organs

358 As a result, CSCs can withstand oxidative damage that would otherwise lead to apoptosis in differentiated tumor cells