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It reveals that altered glutathione and AA homeostasis induced by Trkb deletion in iSPNs is directly linked to early dopaminergic dysfunction and disrupted energy metabolism followed by age-dependent motor impairment and strongly supports the relevance of our model to elucidate the mechanisms underlying the vulnerability of iSPNs in neurodegenerative conditions

Correlation analysis was performed with corAR1, which describes the within group correlation structure as an autoregressive process of order 1, and accounts for correlation between adjoining observations

10.1016/j.neulet.2006.10.062 84 NassiniR.GeesM.HarrisonS.De SienaG.MaterazziS.MorettoN.et al

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Materials and methods Subject population Parents of patients seen from 20082011 in a medically based autism clinic were requested to consent to allow their childs medical information to be anonymously abstracted into a clinical database that contained medical history, physical examination findings and the results of neurological and metabolic testing