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BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission

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Negative ANA : While antinuclear antibodies (ANA) can occasionally be present in up to a third of RA patients, a negative result is clinically useful in ruling out other systemic rheumatic diseases, such as systemic lupus erythematosus (SLE) or mixed connective tissue disease, which can present with similar early joint symptoms but are characterized by specific autoantibodies (Baker, 2026

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