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High cortisol promotes fat storage (especially belly fat) and drives cravings

Both compounds elevate IGF-1 and therefore share the GH axiss theoretical risks (fluid retention, insulin resistance, and the general caution around chronically elevated IGF-1)

Ignore blood sugar and heart health, offering zero metabolic benefits

Eur J Cancer 1995;31A(10):1721

This disparity is ascribed to variations in screening methodologies (eg, prevalent prostate-specific antigen [PSA] testing in affluent nations resulting in overdiagnosis), lifestyle determinants (eg, Western diets abundant in red meat and fat, obesity), aging demographics, and genetic predisposition (eg, elevated risk in populations of African descent)