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In addition, H2O2 may activate transcription by directly oxidising H2O2-responsive transcription factors via oxidation of thiols of cysteine residues in protein

The key function of the complex E1alpha subunit containing the active site is to be the rate limiting enzyme, unidirectionally funneling intermediate metabolites from glucose breakdown to either the oxidative metabolic pathways or fatty acid and cholesterol synthesis [13]

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Roberts stomach cell protection (cytoprotection) appears as Selyes response to damage as such. 22 Roberts small irritant that protects against strong irritant (adaptative cytoprotection) 17 corresponds to Selyes small stress that protects against severe stress (general adaptation)