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The World Health Organization (WHO) pioneered this list with around 200 medicines, and almost fifty years later, the list is only growing, with over 500 drugs making the cut to help meet the medical needs of people across the world

This action, called the incretin effect, accounts for as much as half of the postprandial insulin response and is exploited therapeutically for diabetes treatment through the use of incretin mimetic drugs and inhibitors of dipeptidyl peptidase 4, which degrades GLP-1

The two interact through mechanisms such as the mitochondria-inflammasome axis and epigenetic regulation, collectively promoting vascular remodeling

Diabetes Care 44 , 24382444 (2021)

Similarly, aromatase inhibitors may be less effective in postmenopausal women with obesity due to increased peripheral estrogen production [22]