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In real-world settings, additional causes of discontinuation include high out-of-pocket costs, restrictive insurance coverage, prior authorization requirements, and drug shortages [52]

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This also contributes to diminishing the opportunities for developing resistance, as biofilms are well-known areas where antibiotic resistance mechanisms are cultivated due to the close positioning of bacteria in a shielded environment

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The extension followed 327 participants for an additional year after discontinuation