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In addition to demonstrating in vitro cAMP activity at human and mouse GLP-1R in transfected CHO and in the mouse MIN6 insulinoma cells, MEDI4166 induced glucose-stimulated insulin secretion in INS1 -cells and displayed a desirable profile in rodent disease models

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[Google Scholar] Nohr EA, Vaeth M, Baker JL, Srensen TIA, Olsen J, Rasmussen KM

Some research suggests that GLP-1 agonists may interact with serotonin pathways, increasing activity at certain serotonin receptors, particularly 5-HT2C