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163 Chronic unpredictable stress (CUS) and acute stress both specifically reduce the expression of the gap junction-forming proteins Cx30 and Cx43, 164 and the integrity of the BBB is weakened in mice lacking Cx30 and Cx43

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[1] [3] It occurs in only about 2-3% of the population over the age of 65

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These biological processes are regulated by signaling pathways such as PPAR, TNF, and MAPK (Yang et al., 2022)