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10.1016/j.bbrc.2015.07.009 [DOI] [PubMed] [Google Scholar] 36.Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A

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Earlier initiation may be appropriate when significant comorbidities persist, but timing should be individualized based on surgical procedure type and metabolic status

This review outlines a mechanistic framework for targeting OS in the comorbidity of HTN and DM while identifying critical knowledge gaps, particularly regarding the timing of antioxidant signaling and the development of personalized redox medicine, which may serve as a reference for researchers and clinicians working in this area