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T-REx-SNAP-GLP-1R cells (Fang, Chen, Manchanda, et al ., 2020), generated from parental Flp-In T-REx 293 cells (Thermo Fisher Scientific, MA, USA) by Flp-mediated genomic integration of an insert encoding human GLP-1R with an N-terminal SNAP f -tag and C-terminal SmBiT tag (custom lingen, Germany), with pcDNA5/FRT as the backbone, were maintained in DMEM supplemented with 10% FBS and 1% penicillin/streptomycin
59 Recently, the SURMOUNT-5 trial demonstrated that tirzepatide was superior to semaglutide in obese patients without diabetes with respect to reductions in body weight and waist circumference at week 72
It appears that only in RYGB and SG patients intestinal derived GLP-1 has a true endocrine role, while in healthy individuals, localized, paracrine and neuronal signals primarily define the GLP-1 physiology
Together with its cofactor protein S, protein C inactivates coagulation factors and inhibits thrombin release
