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Noteworthy, PDH represents a connection between glycolysis and the tricarboxylic acid (TCA) cycle

PGC-1 family The members of peroxisome proliferator-activated receptor (PPAR) coactivator 1 (PGC-1) family of transcriptional co-activators have been reported to exert several biological functions like energy metabolism, skeletal muscle fiber type switching, heart development, adaptation to thermogenesis, and endurance-type exercise

FIGURE 1 Over the past few decades, several pharmacological agents have been developed to regulate blood glucose

Fang X, Ardehali H, Min J, Wang F

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