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When sulforaphane enters the cell, it interacts with Keap1, causing it to release Nrf2

Another issue is that the C57Bl/6 strain has 2 substrains, 6N and 6J, which have markedly different susceptibility to APAP [132]

doi: 10.3748/wjg.v19.i4.445

Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, et al: Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals

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