Originally developed for glycemic control, semaglutide promotes glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and, most importantly for MASH, produces significant weight loss through the hypothalamic regulation of appetite and satiety
Proc Natl Acad Sci USA 118 , e2011226118 (2021)
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This analysis showed that semaglutide (both oral and sc) reduces the continuum relative and the absolute risk of MACE, especially in medium to high-risk patients, with no difference between trials evaluating only blood glucose control or cardiovascular events, and also with studies without active comparator, only versus placebo
elife 6:e25496